您當前所在的位置:首頁>>獸醫科技進展

動物源食品中呋喃西林及其代謝物氨基脲研究進展

點擊數:6575  時間:2019-06-26 10:30:21  來源: 信息處      

呋喃西林是一種硝基呋喃類抗菌藥物,曾被廣泛應用于水産養殖過程中。呋喃西林在動物體内的代謝物氨基脲(SEM)會與細胞膜蛋白緊密結合,形成結合态殘留物,穩定而長期存在于動物體内,具有緻癌、緻畸性。本文簡要介紹了呋喃西林藥物的藥理作用及其應用,綜述了兩種應用于SEM檢測的主要方法——高效液相色譜(HPLC)及其聯用技術和免疫分析法的研究進展情況及其優缺點,以及食品中的SEM來源,以期對呋喃西林藥物及其代謝物SEM有一個較為完整的了解,也為進一步開展相關研究奠定理論基礎。



Research Progress on Nitrofurazone and Its Metabolite ofSemicarbazide in Animal-derived Food

Nitrofurazone,as anitrofuran antibiotic,had been widely used inaquaculture. However,the semicarbazide(SEM),a kind of metabolite generated bynitrofurazone within animal's body,could closelyincorporate with cell membrane protein to form bound residues which wouldexisted in animal's body for a long time with carcinogenicity andteratogenicity. In this paper,the pharmacologicaleffects and application of nitrofurazone were briefly introduced. Besides,the research progress,advantages anddisadvantages of the main methods for SEM detection,includinghigh performance liquid chromatography(HPLC)and its combined technology and immunoassay were summarized,the sources of SEM in food was also summarized,hoping to comprehensively recognize the nitrofurazone and itsmetabolite of semicarbazide,and to provide theoreticalfoundation for further research.

全文下載鍊接:http://kns.cnki.net/KCMS/detail/37.1246.S.20190605.1615.030.html



網站首頁 | 網站聲明 | 聯系我們 | 網站幫助 |

版權所有及制作維護:中國動物衛生與流行病學中心

魯ICP備08016398号  公安機關備案号 37020302370412

網站保留所有權,未經許可不得複制、鏡像

http://fv0aqh.dnsxa83.top| http://zw5lz6f.dnsxa83.top| http://720w9qo3.dnsxa83.top| http://nzdm.dnsxa83.top| http://sjvp.dnsxa83.top|